KIFAP3

Kinesin-associated protein 3

  • Alias                                 (According to NCBI)

 
  • FLJ22818
  • GDS
  • KAP3
  • SMAP
  • Smg
  • Smg-GDS
  • dJ190I16.1
  • Smg GDS
  • kinesin-associated protein 3
  • small G protein GDP dissociation stimulator
  • smg GDS-associated protein
  • Kinesin-associated protein 3 (Smg GDS-associated protein).

  • The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein.
  • Location: 1q24.2
  • Orientation: minus strand
  • Size: 153410 bp
  • 20 exons
  • DNA sequence (Human): NC_000001

  • CGH (1q24.2):  Losses (%) -2.5  Gain (%)  11.3  Amplifications (%) 0.0
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 792 amino acids; 91190 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)