KAI1

                                                                                                             (Kangai 1)

  • Alias                                 (According to NCBI)

 
  • 4F9
  • C33
  • CD82 
  • GR15
  • IA4
  • R2 
  • SAR2
  • ST6
  • CD82 antigen
  • R2 leukocyte antigen
  • kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
  • suppressor of tumorigenicity 6
  • CD82 antigen (Inducible membrane protein R2) (C33 antigen) (IA4) (Metastasis suppressor Kangai 1)
    (Suppressor of tumorigenicity-6)

  • This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients.
  • Location:11p11.2
  • Orientation: Plus strand
  • Size: 54,107 bases
  • 10 Exons
  • DNA Sequence: NT_009237

  • CGH (11p11.2):  Losses (%) -7.5  Gain (%)  2.5   Amplifications  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 267 amino acids, 29,625 Da
  • Sub cellular location: Integral membrane protein
  • Protein domains:

                                                 

 
  • Pathways and interactions (According to BioCarta, DIP)
  • Pathways:
  • Interactions:
  • Clinical                            (According to OMIM, PubMed)