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ING1

(Inhibitor of growth family, member 1)

Alias (According to NCBI)	p33ING1 Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds growth inhibitor ING1 inhibitor of growth 1 inhibitor of growth family, member 1 tumor suppressor ING1 Inhibitor of growth protein 1
Description (According to SwissProt)	This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers.
Chromosomal location (According to NCBI, CGH: progenetix)	Location: 13q34 Orientation: Plus strand Size: 8,338 bases 2 Exons DNA Sequence: NT_009952 CGH (13q34): Losses (%) -8.8 Gain (%) 1.3 Amplifications 0.0
Mutations and SNPs (According to HGMD and SNP)	HGMD: SNPs: ING1
m-RNA (According to NCBI and CGAP)	m-RNA Sequence: 4 Transcript variants: NM_005537, NM_198217, NM_198218, NM_198219 c-DNA Libraries: ING1
Protein (According to SwissProt, Swiss2D, PDB,dbPTM)	Size: 422 amino acids; 46780 Da Sub cellular location: Nuclear Protein domains: Protein sequence: Q9UK53 Homologous genes: ING1 PTM: ING1
Pathways and interactions (According to BioCarta, DIP)	Pathways: Downregulated of MTA-3 in ER-negative Breast Tumors Growth Hormone Signaling Pathway How Progesterone Initiates the Oocyte Maturation IL-2 Receptor Beta Chain in T cell Activation Intrinsic Prothrombin Activation Pathway Msp/Ron Receptor Signaling Pathway Multi-step Regulation of Transcription by Pitx2 Interactions: Q9UK53
Tissue (According to GeneNote, PubMed, HPA)	Tissue expression: PubMed Reference Human Protein Atlas (HPA):
Clinical (According to OMIM, PubMed)	OMIM: 601566 PubMed: Early detection Diagnosis Prognosis Therapy