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Alias (According to NCBI)
- CD124
- IL4RA
- interleukin 4 receptor
- Interleukin-4 receptor alpha chain precursor
(IL-4R-alpha) (CD124 antigen) [Contains: Soluble
interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].
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Description
(According to SwissProt)
- This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location: 16p11.2-12.1
- Orientation: plus strand
- Size: 34709 bp
- 11 exons
- DNA sequence (Human):NC_000016
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CGH (16p11.2-12.1): Losses (%) -7.5 Gain (%) 0.0 Amplifications 0.0
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mRNA sequence (Human): NM_000418 , NM_001008699
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Size: 3678 bp, 1106 bp
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cDNA libraries: IL4R
- Size:825 amino acids; 89658 Da
- Catalytic activity:
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Subcellular location: Type I membrane protein. Isoform 2 is secreted.
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Protein domains
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Pathway:
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Selective expression of chemokine receptors during T-cell polarization
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Protein interactions: 3223N
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA): CAB004451
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OMIM: 147781
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PubMed: Early detection Diagnosis Prognosis Therapy