HGF

                                                                                    (Hepatocyte growth factor precursor)

  • Alias                                 (According to NCBI)

 
  • HPTA
  • SF
  • Hepatocyte growth factor (hepapoietin A; scatter factor)
  • hepatopoietin A 
  • lung fibroblast-derived mitogen
  • scatter factor
  • Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A).

  • HGF is structurally similar, if not identical, to scatter factor, a molecule shown to stimulate the dissociation and scattering of epithelial cells. The sequence of HGF has about 35% identity to that of plasminogen and the putative cleavage site of HGF is identical to that of plasminogen. A potent mitogen for hepatocytes, HGF is also known as hepatopoietin A (HBGA)
  •  Location: 7q21.1
  • Orientation: Minus strand
  • Size:71,099 bases
  • 18 Exons
  • DNA Sequence: NT_007933

           

  • CGH (7q21.1):  Losses (%)  -3.8   Gain (%)  8.8  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD:
  • SNPs: HGF
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:728 amino acids; 83133 Da
  • Protein domains:

                                       

                          

  • Protein sequence: P14210
  • Homologous genes: HGF
  • 3D Structure:2HGF                                       
  • PTM: HGF
  • Pathways and interactions (According to BioCarta, DIP)
                              Signaling of Hepatocyte Growth Factor Receptor
  • Clinical                            (According to OMIM, PubMed)