H3F3A

(H3 histone, family 3A)

 

  • Alias                                 (According to NCBI)

 
  • H3.3A
  • H3F3
  • H3 histone, family 3A
  • Histone H3.3.
  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.
  • Location:1q41
  • Orientation: plus strand
  • Size:9282 bp
  • 5  exons
  • DNA sequence (Human): NC_000001

  • CGH (1q41):  Losses (%) -3.8   Gain (%) 8.8    Amplifications 0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:135 amino acids; 15197 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

                                 

 
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)