Erb-b2

                                                                     (v-erb-b2 Erythroblastic leukemia viral Oncogene homolog 2)      

  • Alias                                 (According to NCBI)

 
  • HER2 
  • NEU 
  • NGL
  • TKR1 
  • Avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 2 
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) 
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 
  • Receptor protein-tyrosine kinase erbB-2 precursor (EC 2.7.1.112) (p185erbB2) (NEU proto-oncogene) (C-erbB-2) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

 
  • Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

 
 
  • location: 17q21.1
  • Orientation: Plus strand
  • Size: 5070693 bp
  • 27 exons
  • DNA sequence: NT_010755

                  

  • CGH (17q21.1):  Losses (%)  -2.5 Gain (%)  6.3  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 1255 amino acids    137910.12 Da  
  • Catalytic activity: ATP + a protein tyrosine = ADP + protein tyrosine phosphate
  • Sub cellular location: Type I membrane protein
  • Protein domains:

                           

          
  • Pathways and interactions (According to BioCarta, DIP)

 
  • Clinical                            (According to OMIM, PubMed)