ENO1

Enolase 1, (alpha)

 

  • Alias                                 (According to NCBI)

 
  • ENO1L1
  • MBP-1
  • MPB1
  • NNE
  • PPH
  • MYC promoter-binding protein 1
  • enolase 1, (alpha)
  • enolase 1, (alpha)-like 1
  • phosphopyruvate hydratase
  • Alpha enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Non- neural enolase) (NNE)
    (Enolase 1) (Phosphopyruvate hydratase) (C-myc promoter-binding protein) (MBP-1) (MPB-1)
    (Plasminogen-binding protein).

  • This gene encodes one of three enolase isoenzymes found in mammals; it encodes alpha-enolase, a homodimeric soluble enzyme, and also encodes a shorter monomeric structural lens protein, tau-crystallin. The two proteins are made from the same message. The full length protein, the isoenzyme, is found in the cytoplasm. The shorter protein is produced from an alternative translation start, is localized to the nucleus, and has been found to bind to an element in the c-myc promoter. A pseudogene has been identified that is located on the other arm of the same chromosome.


  • CGH (1p36.3-36.2):  Losses (%) -6.3  Gain (%) 0.0   Amplifications (%) 0.0
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 433 amino acids; 47038  Da   
  • Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.

  • Subcellular location: Cytoplasmic. Can translocate to the plasma membrane in either the homodimeric
    (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M-band. The MBP1
    isoform is nuclear.

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Protein interactions: 6859N

  • Clinical                            (According to OMIM, PubMed)