EEF1A1

Eukaryotic translation elongation factor 1 alpha 1

 

  • Alias                                 (According to NCBI)

 
  • ALPHA
  • EEF-1
  • EEF1A
  • EF-Tu
  • GRAF-1EF
  • MGC16224
  • PTI1
  • eEF1A-1 
  • CTCL tumor antigen
  • EF1a-like protein
  • elongation factor 1 alpha subunit
  • elongation factor 1-alpha 
  • elongation factor Tu
  • eukaryotic translation elongation factor 1 alpha 1
  • eukaryotic translation elongation factor 1 alpha 1-like 14
  • glucocorticoid receptor AF-1 specific elongation factor
  • prostate tumor-inducing protein 1
  • Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor
    Tu) (EF-Tu).

  • This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes.
  • Location: 6q14.1
  • Orientation: minus strand
  • Size: 5,288 bp
  • 8  exons
  • DNA sequence (Human): NC_000006

  • CGH (6q14.1):  Losses (%) -7.5  Gain (%) 0.0   Amplifications(%) 0.0
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 462 amino acids; 50141 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasmic.

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 
  • Clinical                            (According to OMIM, PubMed)