E2F-1

                                                                                      (E2F transcription factor 1)

  • Alias                                 (According to NCBI)

 
  • E2F-1
  • RBBP3
  • RBP3 
  • E2F transcription factor 1
  • retinoblastoma-associated protein 1
  • Transcription factor E2F1 (E2F-1) (Retinoblastoma binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1).

  • The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
  • Location: 20q11.2
  • Orientation: Minus strand
  • Size: 10,724 bases
  • 7 Exons
  • DNA Sequence: NT_028392

  • CGH (20q11.2):  Losses (%)  -11.3  Gain (%)  1.3  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:437 amino acids; 46919 Da
  • Sub cellular location: Nuclear
  • Protein domains:

                                             

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)