CTSD

                                                                                                           (Cathepsin D)

  • Alias                                 (According to NCBI)

 
  • CPSD
  • MGC2311 
  • cathepsin D (lysosomal aspartyl protease)
  • Cathepsin D precursor (EC 3.4.23.5)

  • The protein encoded by this gene is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript.

  • Location: 11p15.5
  • Orientation: Minus strand
  • Size:11,237 bases
  • 9 Exons
  • DNA Sequence: NT_009237

                 

  • CGH (11p15.5):  Losses (%)  -7.5 Gain (%)  2.5  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 412 amino acids; 44552 Da
  • Sub cellular location: Lysosomal
  • Catalytic activity: Specificity similar to, but narrower than, that of pepsin A. Does not cleave
    the 4-Gln
  • Protein domains:

                                               
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)