CHKA

(Choline kinase alpha )

 

  • Alias                                 (According to NCBI)

 
  • CHK 
  • CKI 
  • choline kinase alpha 
  • Choline kinase alpha (EC 2.7.1.32) (CK) (CHETK-alpha).
  • The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.
  • Location: 11q13.2
  • Orientation: minus  strand
  • Size:  68531 bp
  • 0 exons
  • DNA sequence (Human): NC_000011

  • CGH (11q13.2):  Losses (%)  -3.8   Gain (%)   13.8  Amplifications 0.0 
  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD (Human Gene Mutation Database):
  • SNPs: CHKA
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 457 amino acids; 52201 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasmic.

  • Protein domains

 

        

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 
  • Clinical                            (According to OMIM, PubMed)