CHES1

 Checkpoint Suppressor 1

 

  • Alias                                 (According to NCBI)

 
  • SRK
  • C14orf116
  • FOXN3
  • HGNC:20212
  • HTLFL1
  • PRO1635
  • checkpoint suppressor 1
  • chromosome 14 open reading frame 116
  • Checkpoint suppressor 1 (Forkhead box protein N3).

  • Checkpoint suppressor 1 is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway.

  • Location:14q24.3-q32.11
  • Orientation: minus strand
  • Size: 457,751 bp
  •  7 exons
  • DNA sequence (Human): NC_000014


  • CGH ( 14q 24.3 - 32.11) :  Losses (%) -1.3    Gain (%) 10.1   Amplifications  1.3
  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD (Human Gene Mutation Database):
  • SNPs: CHES1
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):NM_005197

  • Size: 7826 bp

  • cDNA libraries:
  • Size: 490 amino acids; 53834 Da   
  • Catalytic activity:

  • Subcellular location: Nuclear.

  • Protein domains

 
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 

 
  • Clinical                            (According to OMIM, PubMed)