CDK6

                                                                                         (cyclin-dependent kinase 6)

  • Alias                                 (According to NCBI)

 
  • PLSTIRE
  • cell division protein kinase 6
  • cyclin-dependent kinase 6
  • Cell division protein kinase 6 (EC 2.7.1.37) (Serine/threonine protein kinase PLSTIRE).

  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.
  • Location:7q21-q22
  • Orientation: Minus strand
  • Size: 219,431 bases
  • 8 Exons
  • DNA Sequence: NT_007933

  • CGH (7q21-22):  Losses (%) -3.8   Gain (%)  8.8   Amplifications  1.3
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 326 amino acids; 36938 Da
  • Catalytic activity: ATP + a protein = ADP + a phosphoprotein
  • Protein domains:

                                         

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)