CA2

(Carbonic anhydrase 2)

 

  • Alias                                 (According to NCBI)

 
  • CA-II 
  • carbonate dehydratase II 
  • carbonic anhydrase B 
  • carbonic anhydrase II 
  • carbonic dehydratase 
  • Carbonic anhydrase II (EC 4.2.1.1) (Carbonate dehydratase II) (CA-II) (Carbonic anhydrase C).
  • CA2 is one of several (at least 7) isozymes of carbonic anhydrase. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis
  • Location:8q22
  • Orientation: plus strand
  • Size: 17476 bp
  • 7 exons
  • DNA sequence (Human):  NC_000008. 

  • CGH (8q22):  Losses (%) -0.0   Gain (%)  23.8   Amplifications  0.0
  • Mutations and SNPs (According to HGMD and SNP)

 

  
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:259 amino acids; 29115 Da
  • Catalytic activity: H2CO3 = CO2 + H2O.

  • Subcellular location: Cytoplasmic

  • Protein domains

     

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:         

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)