• Alias                                 (According to NCBI)

• ASP
• acylation-stimulating protein cleavage product
• complement component 3 
• Complement C3 precursor

• Description   

  (According to SwissProt)

• Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptable to bacteria infection.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 19p13.3-p13.2
• Orientation: minus strand
• Size: 42783 bp
• 41 exons
• DNA sequence (Human): NC_000019.

• CGH (19p13.3 - 13.2):  Losses (%) -11.3    Gain (%)  8.8   Amplifications  0.0

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : C3
•  SNPs: C3 

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):NM_000064
• Size:  5067 bp
• cDNA libraries: C3

• Protein                        (According to SwissProt, Swiss2D, PDB)

• Size: 1663 AA; 187164 Da
• Catalytic activity:
• Subcellular location:
• Protein domains

• Protein sequence (Human):P01024

• Homologous genes: C3

• 2D PAGE: P01024

• 3D Structure:1C3D

• Pathways and interactions (According to BioCarta, DIP)

• Pathway:

           Alternative Complement Pathway

           Cells and Molecules involved in local acute inflammatory response

           Classical Complement Pathway

           Complement Pathway

           Lectin Induced Complement Pathway

•  Protein interactions:

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA):  CAB004209

• Clinical                            (According to OMIM, PubMed)

• OMIM: 120700

• PubMed:    Early detection      Diagnosis         Prognosis        Therapy