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Alias (According to NCBI)
- C-MYC
- c-Myc
- v-myc avian myelocytomatosis viral oncogene homolog
- v-myc myelocytomatosis viral oncogene homolog (avian)
- Myc proto-oncogene protein (c-myc)
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Description
(According to SwissProt)
- Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognize the core sequence CAC [GA] TG. Seems to activate the transcription of growth-related genes.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location: 8q24.12-q24.13
- Orientation: Plus strand
- Size: 5,167 bp
- 3 Exons
- DNA sequence: NT_008046
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CGH (8q24.12- 24.13)): Losses (%) -0.0 Gain (%) 26.3 Amplifications (%) 0.0
- Size: 439 amino acids; 48804 Da
- Sub cellular location: Nuclear
- Protein domains:
- PATHWAYS:
- Cadmium induces DNA synthesis and proliferation in macrophages.
- Erk1/Erk2 Mapk signaling pathway.
- IL-2 Receptor Beta Chain in T cell Activation.
- IL-7 Signal Transduction.
- Inhibition of Cellular Proliferation by Gleevec.
- MAPKinase Signaling Pathway.
- Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha).
- mTOR Signaling Pathway.
- Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells.
- Overview of telomerase protein component gene hTert Transcriptional Regulation.
- p38 MAPK Signaling Pathway.
- Regulation of eIF4e and p70 S6 Kinase.
- Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy.
- Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway.
- Stat3 Signaling Pathway.
- Telomeres, Telomerase, Cellular Aging, and Immortality.
- Tumor Suppressor Arf Inhibits Ribosomal Biogenesis.
- WNT Signaling Pathway.
- Interactions: P01106
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA): CAB000084
- OMIM:190080
- PubMed: Early detection Diagnosis Prognosis Therapy