BCL2L1

                                                                                                     (Apoptosis regulator Bcl-X)   

  • Alias                                 (According to NCBI)

 
  • BCL-XL/S
  • BCL2L
  • BCLX
  • Bcl-X
  • bcl-xS
  • BCL2-like 1
  • Apoptosis regulator Bcl-X (Bcl-2-like 1 protein).

  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.
  • Location: 20q11.21
  • Orientation: Minus strand
  • Size: 58,393 bases
  • 3 Exons
  • DNA Sequence: NT_028392

                 

  • CGH (20q11.21): Losses (%) -2.5  Gain (%)  11.3   Amplifications 0.0
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:233 amino acids; 26049 Da
  • Sub cellular location: Mitochondrial membranes and perinuclear envelope
  • Protein domains

             

                           

  • Pathways and interactions (According to BioCarta, DIP)

  • Clinical                            (According to OMIM, PubMed)