Bax

                                                         (BCL2-associated X protein) 

  • Alias                                 (According to NCBI)

 
  • BCL2-associated X protein
  • apoptosis regulator BAX
  • Apoptosis regulator BAX, membrane isoform alpha.
  • Apoptosis regulator BAX, Cytoplasmic isoform beta.
  • BAX protein, Cytoplasmic isoform gamma. 
  • BAX protein, Cytoplasmic isoform delta.

  • This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein.
  • Location:19q13.3-13.4
  • Orientation: Plus strand
  • Size:6,920 bases
  • 7 Exons
  • DNA Sequence: NT_011109

                          

  • CGH (19q13.3 - 13.4):  Losses (%) -10.0  Gain (%)  6.3   Amplifications 0.0
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 

       
         Name         Size           Location  sequence
Apoptosis regulator BAX, membrane isoform alpha   192 amino acids; 21184 Da      Membrane bound   Q07812
Apoptosis regulator BAX, Cytoplasmic isoform beta   218 amino acids; 24220 Da       Cytoplasmic   Q07814
BAX protein, Cytoplasmic  isoform gamma   41 amino acids; 4678 Da       Cytoplasmic   Q07815
BAX protein, Cytoplasmic isoform delta    143 amino acids; 15772 Da       Cytoplasmic   P55269

                                                         

 

  •  Protein domains:

                                                 

  • Pathways and interactions (According to BioCarta, DIP)

                                               

  • Clinical                            (According to OMIM, PubMed)