APC

                 (Adenomatous polyposis coli protein)

  • Alias                                 (According to NCBI)

 
  • DP2
  • DP2.5
  • DP3
  • FAP 
  • FPC 
  • GS
  • adenomatosis polyposis coli 
  • Adenomatous polyposis coli protein (APC protein).

  • The metabolic function of the APC gene is not known. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
  • Location: 5q21-q22
  • Orientation: Plus strand
  • Size:108,049 bases
  • 16 Exons
  • DNA Sequence: NT_034772

                     

  • CGH (5q21-q22): Losses (%) -8.8   Gain (%)  2.5  Amplifications  0.0
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 2843 amino acids; 311658 Da
  • Protein domains:

                                                    
  • Pathways and interactions (According to BioCarta, DIP)

 
  • Clinical                            (According to OMIM, PubMed)