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Alias (According to NCBI)
- ALDH10
- FALDH
- SLS
- Sjogren-Larsson syndrome
- aldehyde dehydrogenase 10
- aldehyde dehydrogenase 10 (fatty aldehyde dehydrogenase)
- aldehyde dehydrogenase 3 family, member A2
- Fatty aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase, microsomal) (ALDH class 3).
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Description
(According to SwissProt)
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Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location:17p11.2
- Orientation: Plus strand
- Size: 28,817 bases
- 10 Exons
- DNA Sequence: NT_030843
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CGH (17p11.2): Losses (%) -3.8 Gain (%) 5 Amplifications 0.0
- Size:485 amino acids; 54847 Da
- Sub cellular location: Cytoplasmic surface of the endoplasmic reticulum membrane
- Protein domains:
- Pathways: Lysine degradation
- Pyruvate metabolism
- Butanoate metabolism
- Histidine metabolism
- Fatty acid metabolism
- Propanoate metabolism
- Tryptophan metabolism
- Bile acid biosynthesis
- Glycerolipid metabolism
- beta-Alanine metabolism
- Glycolysis / Gluconeogenesis
- 1,2-Dichloroethane degradation
- Arginine and proline metabolism
- Limonene and pinene degradation
- Ascorbate and aldarate metabolism
- Valine, leucine and isoleucine degradation
- Interactions:
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA):
- OMIM: 270200
- PubMed: Early detection Diagnosis Prognosis Therapy