AKT3

               (RAC-gamma serine/threonine protein kinase)

  • Alias                                 (According to NCBI)

 
  • DKFZP434N0250
  • PKBG
  • PRKBG
  • RAC-PK-gamma
  • RAC-gamma
  • STK-2
  • RAC-gamma serine/threonine protein kinase
  • protein kinase B gamma
  • serine threonine protein kinase, Akt-3
  • v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
  • RAC-gamma serine/threonine protein kinase (EC 2.7.1.-) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

  • The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1).
  • Location:1q43-q44
  • Orientation: Minus strand
  • Size: 355,351 bases
  • 13 Exons
  • DNA Sequence: NT_004836

      CGH (1q43-q44): Losses (%) -3.8   Gain (%)  8.8   Amplifications  0.0
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 

                            
  • Size:479 amino acids; 55774 Da
  • Sub cellular location: Cytoplasmic and membrane associated after cell stimulation leading to its translocation.
  • Protein domains:
         

                                               
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)