ABCB4

                 (P glycoprotein 3/multiple drug resistance 3)

 

  • Alias                                 (According to NCBI)

 
  • ABC21
  • MDR2
  • MDR2/3
  • MDR3
  • PFIC-3 
  • PFIC3
  • PGY3
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4 
  • P glycoprotein 3/multiple drug resistance 3
  • P-glycoprotein-3/multiple drug resistance-3
  • Multidrug resistance protein 3 (P-glycoprotein 3).

  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile.
  • Location:7q21.1
  • Orientation: Minus strand
  • Size: 75,504 bases
  • 32 Exons
  • DNA Sequence: NT_007933, NT_079595 

       

 

  • CGH (7q21.1): Losses (%) -3.8   Gain (%)  8.8   Amplifications  1.3
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:1279 amino acids; 140682 Da
  • Sub cellular location: Integral membrane protein
  • Protein domains:

                                                    
  • Pathways and interactions (According to BioCarta, DIP)

  • Clinical                            (According to OMIM, PubMed)