Version I

  Click here for version II of Oral Cancer Gene Database

 Gene List
 Keyword Search
 Interactome map

 

Oral cancer is the sixth common malignancy and a major cause of cancer morbidity and mortality worldwide and buccal mucosa is one most commonly affected sites. Worldwide over 350,000 to 400,000 new cases of cancer found each year. Cancers of Head and Neck comprises ~27 % of total cancers seen in males at Tata Memorial Centre. Of these ~12 % are from the Oral cavity. In the post genomic era, efforts to understand oral cancer are aimed at obtaining genomic and proteomic profiles which generate enormous data. Thus the challenge is to analyze the data effectively and utilize the information for diagnosis, prognosis and treatment.

The existing database on oral cancer genes OrCGDB (http://www.tumor-gene.org/Oral/oral.html) has information only about 15 genes without a search engine and Interactome map. We are developing a more user friendly database that would provide the scientist, information and external links from one place. At present the data base contains 242 genes mined from PubMed database (34 genes), Shillitoe (http://www.upstate.edu/microb/shillite/Published_Oral_Cancer_Genes.htm) medline search (90 genes) and the gene list reported in full text articles from microarray and proteomics studies (118 genes).

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Click here to get list of all 242 genes in the database. For each gene description and hyperlink to its PubMed reference. Clicking on gene name gives detailed information on aliases, function, chromosomal location, mutations and SNPs, mRNA expression, Protein information, pathways involved and interacting proteins, expression of genes in different tissues, and clinical correlates.

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Keyword search using Gene name or gene symbol, Chromosomal location, C.G.H (in %), and Molecular weight. Advanced search option for multiple searches from the above parameters is also available.

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Interactome Map shows the interaction between genes for a particular biological process and molecular functions. The connecting line between the two genes gives the PubMed reference for their interactions. Clicking on the gene name gives detailed information. 


Oral Cancer Gene Database (Version I) consists of 242 genes which has been published in :

Gadewal NS, Zingde SM., Database and interactome map of genes involved in oral cancer, Online J Bioinformatics, 8 (1) 41-44, 2007.

 

For suggestion and comments:  Curator: Mr. Nikhil S. Gadewal mailto:ngadewal@actrec.gov.in)

                                                           Science Editor: Dr. Surekha M. Zingde  (szingde@actrec.gov.in)