Histone methyl transferase (Homo sapiens)

Histone methyltransferases play an important role in controlling gene expression through site-specific methylation of lysines in core and linker histones within chromatin. Histone lysine methylation can either activate or repress transcription, depending on the residue modified and the degree of methylation of its ε-amino group [Bannister and Kouzarides,(2005)].

Enzymes

Chromosome

Location

Site of Modification
SUV39H1 Chromosome: X Xp11.23 H3K9me1, me2, me3
EHMT2 Chromosome: 6  6p21.31 H3K9me1, me2, me3, H3K27me1, me2, me3
SETD8 Chromosome:  12 12q24.31 H4K20me1, me2
EZH2 Chromosome: 7 7q35-q36 H3K9me1, me2, me3, H3K27me1, me2, me3
EHMT1 Chromosome: 9 9q34.3 H3K9me1, me2, me3
SUV39H2 Chromosome: 10 10p13 H3K9me1, me2, me3
SETDB1 Chromosome: 1 1q21 H3K9me1, me2, me3
SETDB2 Chromosome: 13 13q14 -
SMYD3 Chromosome: 1 1q44 H3K4
SETD1A Chromosome: 16 16p11.2 H3K4me1
SETD2 Chromosome: 3 3p21.31 H3K36me1, me2, me3
SETMAR Chromosome: 3 3p26.2 H3K4, H3K36
MLL3 Chromosome: 7 7q36 H3K4
NSD 1 Chromosome: 5 5q35 H3K36me1, me2, me3, H4K20
NSD 3 Chromosome: 8 8p11.2 H3K4me2, H3K27me2, me3
SUV420H1 Chromosome: 11 11q13.2 H4K20me1, me2
SUV420H2 Chromosome: 19 19q13.42 H3K9me1, me2, me3, H4K20me1, me2
CARM1 Chromosome: 19 19p13.2 H3R2, H3R17me2, H3R26
SETD7 Chromosome: 4 4q28 H3K4me1, H4K20me1, me2
PRMT5 Chromosome: 14 14q11.2-q21 H3R8me2
DOT1L Chromosome: 19 19p13.3 H3K79me1, me2
PRMT1 Chromosome: 19 19q13.3 H4R3

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