Histone DeACETYLASE (Homo sapiens)

The identification and characterization of numerous transcriptional regulators possessing histone acetyl transferase or HDAC activites has validated the prediction that histone acetylation plays a critical role in transcriptional regulatory mechanisms. Human HDACs are grouped into three classes based on their primary homolog , Saccharomyces cerevisiae HDAC.

Class I HDAC : HDAC(1,2,3,8 and 11) are homologous to yRPD3,share a compact structure and are predominantly nuclear proteins expressed in most tissue and cell lines.

Class II HDAC: It is homologous to yHDAC1 and subdivided into two subclasses .

• Class IIA having HDAC (4,5,7,9) and its splice variant MITR

•  Class IIB having HDAC(6,10) based on sequence homolog and domain organizatin.

Class III HDAC: It is homologous to ySIRT2 and shows no homology to class I and II proteins

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