Phosphorylation 

Little is known about histone phosphorylation and gene expression. The addition of a phosphate group on histones has important implications in signal transductions. It is an important regulatory event catalyzed by kinases.

 

Variant

Site of modification

Enzymes

Role

H1.0

S170

-

-

H1.2

T30

-

-

H1.2

S172

-

-

H1.3

T17

-

-

H1.3

S36

-

-

H1.4

T17

-

-

H1.4

S186

-

-

H1.5

T137

-

-

H1.t

T58

-

-

H1.x

S1

-

-

H1.x

S48

-

-

H2A,H2A1A,H2A1B,H2A1C,H2A1D,H2A1E,

H2A1H,H2A1J,H2A.1,H2A.3,H2A2A,H2A2C,

H2B1N

S1

RPS6KA5

Transcription Repression

H2Ax

S139

ATM

DNA Damage and Indicator of apoptosis

Macro H2A.1

 

T128

-

-

T176

-

-

H2B,H2B1B,H2B1C/E/F/G/I,H2B1D,

H2B1H,H2B1J,H2B1L,H2B1M,H2B1N,

H2B1O,H2B2E,H2B2F,H2B3B

S14

STK4/MST1

Apoptotic chromatin condensation

H3.1,H3.2,H3.3

T3

GSG2/haspin

Metaphase chromosome alignment

S10

MSK1,AURKB,RPS6KA5

 

GeneActivation,

Chromosome condensation and Cell-cycle progression

T11

DAPK3/ZIPK

-

S28

RPS6KA5/MSK1/2,

MLTK isoform1

 AURKB

Cell proliferation

H3.1t

S10

AURKB,  RPS6KA5

GeneActivation,

Chromosome condensation and Cell-cycle progression

CENPA

S6

AURKA/STK6, AURKB/STK12

Essential for kinetochore function

S16

-

-

S18

-

-

H4

S1

CK II

-

S57

-

-
 

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