Biotinylation
Biotinylation
is the process of covalently attaching a biotin tag to a molecule or surface.
Biotinylation of histones plays a role in the regulation of gene expression [Peters
DM et al,(2002)], cell proliferation
| Variant | Site of modification |
Enzyme |
Role |
| H2A | K9 | Biotinidase | Cell proliferation, Gene silencing and Cellular response to DNA damage. |
| H2A | K13 | Biotinidase | Cell proliferation, Gene silencing and Cellular response to DNA damage. |
| H2A | K127 | Biotinidase | Cell proliferation, Gene silencing and Cellular response to DNA damage. |
| H2A | K129 | Biotinidase | Cell proliferation, Gene silencing and Cellular response to DNA damage. |
| H2A.X | K9 | Biotinidase | Cell proliferation, Gene silencing and Cellular response to DNA damage. |
| H2A.X | K13 | Biotinidase | Cell proliferation, Gene silencing and Cellular response to DNA damage. |
| H3 | K4 | Biotinidase | |
| H3 | K9 | Biotinidase | |
| H3 | K18 | Biotinidase | |
| H4 | K8 | Biotinidase | Response to DNA damage |
| H4 | K12 | Biotinidase | Response to DNA damage |