Biotinylation

 

Biotinylation is the process of covalently attaching a biotin tag to a molecule or surface. Biotinylation of histones plays a role in the regulation of gene expression [Peters DM et al,(2002)], cell proliferation [Stanley JS et al,(2001)] and the cellular response to DNA damage [Janos Zempleni et al, (2005)].

 

Variant Site of modification

Enzyme

Role

H2A K9 Biotinidase  Cell proliferation, Gene silencing and Cellular response to DNA damage.
H2A K13 Biotinidase Cell proliferation, Gene silencing and Cellular response to DNA damage.
H2A K127 Biotinidase Cell proliferation, Gene silencing and Cellular response to DNA damage.
H2A K129 Biotinidase Cell proliferation, Gene silencing and Cellular response to DNA damage.
H2A.X K9 Biotinidase Cell proliferation, Gene silencing and Cellular response to DNA damage.
H2A.X K13 Biotinidase Cell proliferation, Gene silencing and Cellular response to DNA damage.
H3 K4 Biotinidase  
H3 K9 Biotinidase  
H3 K18 Biotinidase  
H4 K8 Biotinidase Response to DNA damage
H4 K12 Biotinidase Response to DNA damage

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