Histone H2B (Homo sapiens)

The N terminus tail of histone H2B is essential for chromatin condensation. [Anne-Elisabeth de la Barre et al ,(2001) ]

It is markedly deficient in variants. However research has reported two testis specific variants of H2B.[Kavitha Sarma et al,(2005)]. These appear to have very specialized functions in chromatin compaction and transcription, repression, particularly during gametogenesis [Rohinton T. Kamakaka et al ,(2005) ]

GENE MAP LOCUS

Histone Variants

No. of Amino Acids

Molecular Weight [Unmodified]

Theoretical pI

Histone H2B

126 AA

13906.1 Da

10.31

Histone H2B Type 1B

126 AA

13950 Da

10.32

Histone H2B Type1C/E/F/G/I

125 AA

13819 Da

10.32

Histone H2B Type 1D

126 AA

13936 Da

10.32

Histone H2B Type 1H

126 AA

13892 Da

10.32

Histone H2B Type 1J

126 AA

13904 Da

10.32

Histone H2B Type 1L

126 AA

13952 Da

10.32

Histone H2B Type 1M

126 AA

13989 Da

10.32

Histone H2B Type 1N

126 AA

13922 Da

10.32

Histone H2B Type 1O

126 AA

13906 Da

10.32

Histone H2B Type 2E

126 AA

13920 Da

10.32

Histone H2B Type 2F

126 AA 13920 Da 10.32

Histone H2B Type 3B

126 AA 13908 Da 10.32

Histone H2B Type WT

175 AA 19599 Da 10.53

Testis-specific histone H2B

127 AA

14167.5 Da

10.31

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

                                                                                                                                               

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