Histone H2a

Featuring a main globular domain and a long N terminal tail, histone H2A is involved with the structure of the nucleosomes in form of "beads and string"arrangement.H2A is the only one with a real cluster of DNA binding sites localized in a short region that is defined structurally [ Danuta Balicki et al ,(2002)].

 It has the largest number of variants like H2AZ which is conserved through evolution. Others such as macro H2A and H2ABbd are restricted to vertebrates or mammals [ Rohinton T. Kamakaka et al ,(2005) ]

GENE MAP LOCUS

Histone Variants No.  of Amino Acids

Molecular Weight [Unmodified]

Theoretical pI
Histone H2A 130AA 13995.3 Da 10.88
Histone H2A Type 1a 131 AA 14234 Da 10.86
Histone H2A Type 1B 130 AA 14135 Da 11.05
Histone H2A Type 1C 130 AA 14105 Da 11.05
Histone H2A Type 1D 130 AA 14107 Da 10.90
Histone H2A Type 1E 130 AA 14135 Da 11.05
Histone H2A Type 1H 128 AA 13906 Da 10.88
Histone H2A Type 1J 128 AA 13936 Da 10.88
Histone H2A.1 130 AA 14091 Da 10.90
Histone H2A Type 2A 130 AA 14095 Da 10.90
Histone H2A Type 2C 129 AA 13988 Da 10.90
Histone H2A.3 130 AA 14121 Da 11.05
Histone H2AV 128 AA 13509 Da 10.58
Histone H2A.Z 128 AA 13553   Da 10.58
Histone H2A.x 143 AA 15145   Da 10.74
Histone H2A.Bbd 115 AA 12713   Da 10.67
Macro H2A.1 372 AA 39617   Da 9.78
Macro H2A.2 372 AA 40058 Da 9.71
 
 

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