Histone H1
H1 is present in half the amount of the total histones. It features a central globular domain and long C and N terminal tails .It helps to pack the 'beads on a string' structure into the '30nm solenoid' structure.
It seals off the nucleosome at the location at which the linker DNA enters and leaves. Specifically, the H1 protein binds to the linker DNA (approximately 80 nucleotides in length) region between the histone beads, helping stabilize the zig-zagged 30nm chromatin fiber.
|
Histone Variants |
No of Amino Acids |
Molecular Weight [Unmodified] |
Theoretical pI |
|
194 AA |
20863 Da |
10.84 |
|
|
215 AA |
21842 Da |
10.99 |
|
|
213 AA |
21365 Da |
10.94 |
|
|
221 AA |
22350 Da |
11.02 |
|
|
219 AA |
21865 Da |
11.03 |
|
|
226 AA |
22580 Da |
10.91 |
|
| Histone H1.t | 207AA | 22019Da | 11.71 |
| Histone H1.x | 213AA | 22487 Da | 10.76 |