Citrullination
Deimination involves the conversion of an arginine to citrulline, catalyzed by PADI4 enzyme. This process antagonizes the activatory effect of arginine methylation since citrulline prevents arginines from being methylated.
| Variant | Site of modification |
Enzyme |
Role |
|
H2A,H2A1A,H2A1B,H2A1C,H2A1D,H2A1E, H2A1H,H2A1J,H2A.1,H2A.3,H2A2A,H2A2C |
R2 | - | - |
| H3.1,H3.2,H3.3 | R8 | PADI4 | Impairs methylation and Represses transcription |
| R17 | PADI4 | Impairs methylation and Represses transcription |