This mark is reported to be linked with DNA damage response.

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H4K20me2 infosheet
Modified variants-
Modified Isoforms Histone H4
Writer/s Lysine Methyltransferase 5A, Lysine Methyltransferase 5B, Lysine Methyltransferase 5C, Nuclear Receptor Binding SET Domain Protein 1
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Sites of Lysine Methylation H3K14me2, H3K27me2, H3K27me3, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3, TH2BK110me, TH2BK117me, TH2BK36me, TH2BK7me