Histone Serine/threonine/tyrosine Phosphorylation

Phosphorylation is mediated by 'Kinases' on histone proteins. This modification occurs on Ser/Thr/Tyr residues using ATP as the phosphate donor. Phosphate groups have an intrinsic charge and therefore give an overall negative charge to modified amino acids these residues. Each phosphate group adds ~95 Da to the histone molecular weight.


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Sites of histone Serine/threonine/tyrosine Phosphorylation
Site of modification Writers Erasers
HILS1T39ph--
HILS1S7ph--
HILS1S29ph--
HILS1S31ph--
HILS1S48ph--
HILS1S62ph--
HILS1S65ph--
HILS1S74ph--
HILS1S145ph--
HILS1S152ph--
HILS1Y78ph--
TH2BT116ph--
TH2BS5ph--
H2AS139ph--
H3S10ph Conserved Helix-loop-helix Ubiquitous Kinase, Mitogen-activated Protein Kinase Kinase Kinase 8, Ribosomal Protein S6 Kinase A5, Ribosomal Protein S6 Kinase A4, Aurora Kinase B, P21 Protein (Cdc42/Rac)-activated Kinase 2 Dual Specificity Protein Phosphatase 1
H3S28ph Ribosomal Protein S6 Kinase A5, Ribosomal Protein S6 Kinase A4-