Histone Lysine Ubiquitination

Ubiquitination is a bulky modification and each ubiquitin group adds ~8.5 kDa. Ubiquitination is catalyzed by a group of ligases named 'Lysine ubiquitinases'. Only H2A and H2B are known to undergo ubiquitination in rats.

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Sites of histone Lysine Ubiquitination
Site of modification Writers Erasers
H2AK119ub Ring Finger Protein 1, Ring Finger Protein 2 SWIRM And MPN Domains 1
H2BK120ub Ring Finger Protein 20, Ring Finger Protein 40, Ring-box 1-