Histone Lysine Methylation

Methylation is one of the well-studied modifications on histones. Mono- (me1), di- (me2) and tri-methylation (me3) are modifications carried out by enzymes called 'lysine methyltransferase'. The methyl donor is S-Adenosyl methionine. Each methyl moiety adds ~14 Da to the histone proteins.


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Sites of histone Lysine Methylation
Site of modification Writers Erasers
TH2BK36me--
TH2BK110me--
TH2BK7me--
H3K4me1 SET Domain Containing (lysine Methyltransferase) 7 Lysine Demethylase 1A
H3K4me2 Nuclear Receptor Binding SET Domain Protein 3 Lysine Demethylase 1A, Lysine Demethylase 5A, Lysine Demethylase 5D
H3K4me3 Lysine Methyltransferase 2A, Lysine Methyltransferase 2C, Lysine Methyltransferase 2B, PR/SET Domain 9, SET Domain Containing 1A, SET Domain Containing 1B, SET And MYND Domain Containing 3 Lysine Demethylase 5A, PHD Finger Protein 8, Lysine Demethylase 2B, Lysine Demethylase 5B, Lysine Demethylase 5C, Ribosomal Oxygenase 1
H3K9me1 Euchromatic Histone Lysine Methyltransferase 2 Lysine Demethylase 1A, Lysine Demethylase 3A
H3K9me2 Euchromatic Histone Lysine Methyltransferase 2, Euchromatic Histone Lysine Methyltransferase 1, PR/SET Domain 2 Lysine Demethylase 1A, PHD Finger Protein 8, Lysine Demethylase 3A, Lysine Demethylase 4C, Lysine Demethylase 4D, Lysine Demethylase 7A, Lysine Demethylase 1B
H3K9me3 SET Domain, Bifurcated 1, Suppressor Of Variegation 3-9 Homolog 1, Suppressor Of Variegation 3-9 Homolog 2 Lysine Demethylase 4C, Lysine Demethylase 4D, Lysine Demethylase 4A, Lysine Demethylase 4B
H3K14me2--
H3K27me2 Nuclear Receptor Binding SET Domain Protein 3, Enhancer Of Zeste 1 Polycomb Repressive Complex 2 Subunit, Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit PHD Finger Protein 8, Lysine Demethylase 7A, Lysine Demethylase 6B
H3K27me3 Nuclear Receptor Binding SET Domain Protein 3, Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit Lysine Demethylase 6B, Lysine Demethylase 6A
H3K36me2 SET Domain And Mariner Transposase Fusion Gene, Nuclear Receptor Binding SET Domain Protein 1, SET And MYND Domain Containing 2, ASH1 Like Histone Lysine Methyltransferase Lysine Demethylase 2B, Lysine Demethylase 2A, Lysine Demethylase 8
H3K36me3 SET Domain Containing 2, Nuclear Receptor Binding SET Domain Protein 2 Ribosomal Oxygenase 1, Lysine Demethylase 4A
H3K79me2 DOT1 Like Histone Lysine Methyltransferase-
H3K79me3 DOT1 Like Histone Lysine Methyltransferase-
H4K20me1 Nuclear Receptor Binding SET Domain Protein 2, Lysine Methyltransferase 5A PHD Finger Protein 8
H4K20me2 Nuclear Receptor Binding SET Domain Protein 1, Lysine Methyltransferase 5A, Lysine Methyltransferase 5B, Lysine Methyltransferase 5C-
H4K20me3 Nuclear Receptor Binding SET Domain Protein 2, Lysine Methyltransferase 5B, Lysine Methyltransferase 5C-
TH2BK117me--