Histone Lysine AcetylationHistone acetylation is predominantly associated with transcriptional activation. Acetylation occurs exclusively on lysine residues of histones by enzymes called as the 'lysine acetyltransferase'. The acetyl-CoA acts as the acetyl group donor. Acetylation causes neutralization of the positively charged lysine residues. Acetylation increases the weight of histone peptide by ~42 Da per acetyl moiety.
Download table as ExcelSites of histone Lysine Acetylation Site of modification | Writers | Erasers |
HILS1K32ac | - | - |
HILS1K58ac | - | - |
HILS1K96ac | - | - |
HILS1K158ac | - | - |
TH2BK7ac | - | - |
TH2BK14ac | - | - |
TH2BK22ac | - | - |
TH2BK48ac | - | - |
TH2BK118ac | - | - |
H3K9ac |
Elongator Complex Protein 3,
Histone Acetyltransferase KAT2A,
Histone Acetyltransferase PCAF |
Sirtuin-1,
Sirtuin 6 |
H3K14ac |
Histone Acetyltransferase KAT2A,
Bifunctional Protein NCOAT,
Circadian Locomoter Output Cycles Protein Kaput,
General Transcription Factor IIIC Subunit 4,
Lysine Acetyltransferase 6A | - |
H3K18ac |
Elongator Complex Protein 3,
CREB Binding Protein,
E1A Binding Protein P300 | - |
H3K23ac | - | - |
H3K24ac | - | - |
H3K27ac |
CREB Binding Protein,
E1A Binding Protein P300 | - |
H3K56ac |
CREB Binding Protein,
E1A Binding Protein P300 |
Sirtuin 6,
Histone Deacetylase 1,
Sirtuin 2,
Sirtuin 3 |
H4K5ac |
Histone Acetyltransferase KAT2A,
CREB Binding Protein,
E1A Binding Protein P300,
Lysine Acetyltransferase 5,
Lysine Acetyltransferase 7,
Histone Acetyltransferase 1 | - |
H4K8ac |
Histone Acetyltransferase KAT2A,
Bifunctional Protein NCOAT,
CREB Binding Protein,
E1A Binding Protein P300,
Lysine Acetyltransferase 5,
Lysine Acetyltransferase 7 | - |
H4K12ac |
Histone Acetyltransferase KAT2A,
CREB Binding Protein,
E1A Binding Protein P300,
Lysine Acetyltransferase 5,
Lysine Acetyltransferase 7,
Histone Acetyltransferase 1 | - |
H4K16ac |
Histone Acetyltransferase KAT2A,
CREB Binding Protein,
E1A Binding Protein P300,
Lysine Acetyltransferase 5 |
Sirtuin-1,
Sirtuin 2 |