Histone Isoforms

Histone isoforms are expressed only in S-phase of cell cycle and therefore referred as replication-dependent histones. These are found in numerous clusters with multiple histone genes differing in few amino acids. These class of histone gene lack a poly(A) tail but have a short highly conserved stem-loop structure in their 3′ untranslated region.

Types of histone isoforms Histone H2A, Histone H2B, Histone H3, Histone H4