Histone Lysine demethylase

Histone methylation marks are involved in gene regulation. These marks are removed by lysine demethylases.

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Different histone Lysine demethylase
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Lysine Demethylase 1AKDM1AH3K4me1, H3K4me2, H3K9me1, H3K9me2
Lysine Demethylase 1BKDM1BH3K9me2
Lysine Demethylase 2AKDM2AH3K36me2
Lysine Demethylase 2BKDM2BH3K4me3, H3K36me2
Lysine Demethylase 3AKDM3AH3K9me1, H3K9me2
Lysine Demethylase 4AKDM4AH3K9me3, H3K36me3
Lysine Demethylase 4BKDM4BH3K9me3
Lysine Demethylase 4CKDM4CH3K9me2, H3K9me3
Lysine Demethylase 4DKDM4DH3K9me2, H3K9me3
Lysine Demethylase 5AKDM5AH3K4me2, H3K4me3,
Lysine Demethylase 5BKDM5BH3K4me3
Lysine Demethylase 5CKDM5CH3K4me3
Lysine Demethylase 5DKDM5DH3K4me2
Lysine Demethylase 6AKDM6AH3K27me3
Lysine Demethylase 6BKDM6BH3K27me2, H3K27me3
Lysine Demethylase 7AKDM7AH3K9me2, H3K27me2
Lysine Demethylase 8KDM8H3K36me2
PHD Finger Protein 8PHF8H3K4me3, H3K9me2, H3K27me2, H4K20me1
Ribosomal Oxygenase 1RIOX1H3K4me3, H3K36me3