Histone Lysine acetyltransferase
The acetylation of histones is mediated by Lysine acetyltransferases catalyze the transfer of acetyl group from acetyl-CoA to the ε-amino group of specific lysine residues. This neutralizes the positive charge of the lysines and alters the histone-DNA interaction. There are total twelve unique proteins reported to have the histone acetyltransferases activity in rats.
| Enzyme (UniprotKB recommended name) | Coding gene/s | Site of histone modification |
|---|---|---|
| Bifunctional Protein NCOAT | MGEA5 | H3K14ac, H4K8ac |
| Circadian Locomoter Output Cycles Protein Kaput | CLOCK | H3K14ac |
| CREB Binding Protein | CREBBP | H3K18ac, H3K27ac, H3K56ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac |
| E1A Binding Protein P300 | EP300 | H3K18ac, H3K27ac, H3K56ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac |
| Elongator Complex Protein 3 | ELP3 | H3K9ac, H3K18ac |
| General Transcription Factor IIIC Subunit 4 | GTF3C4 | H3K14ac |
| Histone Acetyltransferase 1 | HAT1 | H4K5ac, H4K12ac |
| Histone Acetyltransferase KAT2A | KAT2A | H3K9ac, H3K14ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac |
| Histone Acetyltransferase PCAF | KAT2B | H3K9ac |
| Lysine Acetyltransferase 5 | KAT5 | H4K5ac, H4K8ac, H4K12ac, H4K16ac |
| Lysine Acetyltransferase 6A | KAT6A | H3K14ac |
| Lysine Acetyltransferase 7 | KAT7 | H4K5ac, H4K8ac, H4K12ac |