Histone Lysine acetyltransferase

The acetylation of histones is mediated by Lysine acetyltransferases catalyze the transfer of acetyl group from acetyl-CoA to the ε-amino group of specific lysine residues. This neutralizes the positive charge of the lysines and alters the histone-DNA interaction. There are total twelve unique proteins reported to have the histone acetyltransferases activity in rats.

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Different histone Lysine acetyltransferase
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Bifunctional Protein NCOATMGEA5H3K14ac, H4K8ac
Circadian Locomoter Output Cycles Protein KaputCLOCKH3K14ac
CREB Binding ProteinCREBBPH3K18ac, H3K27ac, H3K56ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac
E1A Binding Protein P300EP300H3K18ac, H3K27ac, H3K56ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac
Elongator Complex Protein 3ELP3H3K9ac, H3K18ac
General Transcription Factor IIIC Subunit 4GTF3C4H3K14ac
Histone Acetyltransferase 1HAT1H4K5ac, H4K12ac
Histone Acetyltransferase KAT2AKAT2AH3K9ac, H3K14ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac
Histone Acetyltransferase PCAFKAT2BH3K9ac
Lysine Acetyltransferase 5KAT5H4K5ac, H4K8ac, H4K12ac, H4K16ac
Lysine Acetyltransferase 6AKAT6AH3K14ac
Lysine Acetyltransferase 7KAT7H4K5ac, H4K8ac, H4K12ac