Sites of histone Lysine methylation
Site of modification Writers Erasers
H4K20me1 N-lysine methyltransferase KMT5A PHD finger protein 8
H4K20me2
H4K20me3 Histone-lysine methyltransferase 5B, Histone-lysine N-methyltransferase 5C
H3K9me2 Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase EHMT2, Histone-lysine N-methyltransferase EHMT1 Lysine-specific demethylase PHF2, Lysine-specific demethylase 3A
H3K9me3 Aurora kinase B, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SETDB2 Lysine (K)-specific demethylase 4A, Lysine (K)-specific demethylase 4B, Lysine (K)-specific demethylase 4C, lysine (K)-specific demethylase 4D
H3K4me2 Histone-lysine N-methyltransferase MLL5, Protein arginine N-methyltransferase 6 Lysine-specific histone demethylase 1A, Lysine-specific demethylase 5B
H3K4me3 Histone-lysine N-methyltransferase MLL2, Protein arginine N-methyltransferase 6 Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C
H3K4me1
H3K36me1 Histone-lysine N-methyltransferase ASH1L, Histone-lysine N-methyltransferase, Histone-lysine N-methyltransferase SETD2
H3K79me1 Histone-lysine N-methyltransferase, H3 lysine-79 specific
H3K9me1 Histone-lysine N-methyltransferase EHMT2, Histone-lysine N-methyltransferase EHMT1, Histone-lysine N-methyltransferase EZH2 Lysine-specific histone demethylase 1A, Lysine-specific demethylase 3A
H3K27me2 Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase EZH1 Lysine-specific demethylase 6B
H3K27me3 Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase EZH1 Lysine-specific demethylase 6B
H3K27me Histone-lysine N-methyltransferase EHMT2, Histone-lysine N-methyltransferase EHMT1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase EZH1, Protein Jumonji Lysine-specific demethylase 6B
H1K34me
H1k46me
H1K63me
H1K106me
H1K26me
H3K122me
H3K36me2 N-lysine methyltransferase SMYD2 lysine (K)-specific demethylase 2A, lysine (K)-specific demethylase 2B, Lysine (K)-specific demethylase 8
H3K36me3 Ribosomal oxygenase 1 , Lysine (K)-specific demethylase 4A
H3K79me2 Histone-lysine N-methyltransferase, H3 lysine-79 specific
H3K79me3 Histone-lysine N-methyltransferase, H3 lysine-79 specific