H3K4me2 is known for active transcription and is mediated by MLL5.

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H3K4me2 infosheet
Modified variantsHistone H3.3, Histone H3.3C
Modified IsoformsHistone H3.1, Histone H3.2
Writer/s Histone-lysine N-methyltransferase MLL5, Protein Arginine N-methyltransferase 6
Eraser/s Lysine-specific Demethylase 5B, Lysine-specific Histone Demethylase 1A
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Sites of Lysine Methylation H1K106me, H1K26me, H1K34me, H1k46me, H1K63me, H3K122me, H3K27me, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3