Histone Serine/threonine/tyrosine Phosphorylation

Another important modification that occurs on histones is phosphorylation (ph) that is mediated by 'Kinases'. This modification occurs on Ser/Thr/Tyr residues using ATP as the donor. Phosphate groups have an intrinsic charge and hence when attached to Ser/Thr/Tyr, it gives an overall negative charge to these residues.


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Sites of histone Serine/threonine/tyrosine Phosphorylation
Site of modification Writers Erasers
H4S1ph--
H4S47ph Serine/threonine-protein Kinase PAK 2-
H3S10ph Aurora Kinase B, Aurora Kinase C, Ribosomal Protein S6 Kinase Alpha-4, Ribosomal Protein S6 Kinase Alpha-5, Ribosomal Protein S6 Kinase Alpha-3-
H3T3ph Serine/threonine-protein Kinase Haspin-
H3T6ph--
H3T11ph--
H3Y41ph Tyrosine-protein Kinase JAK2-
H3S28ph Aurora Kinase B, Aurora Kinase C, Ribosomal Protein S6 Kinase Alpha-4, Ribosomal Protein S6 Kinase Alpha-5-
H3S31ph--
H2BS14ph Serine/threonine-protein Kinase 4-
H2BS36ph--
H2AS139ph Serine/threonine-protein Kinase ATR, Serine-protein Kinase ATM, DNA-dependent Protein Kinase Catalytic Subunit-
H2BS32ph Ribosomal Protein S6 Kinase Alpha-3-
H2AT120ph--
H2BT119ph--
H1S27ph--
H1S140ph--
H1S177ph--
H1S8ph--
H1T155ph--
H1S172ph--
H1S187ph--
H1T18ph--
H2AS1ph Ribosomal Protein S6 Kinase Alpha-5-
H2AY142ph Tyrosine-protein Kinase BAZ1B, Eyes Absent Homolog 1, Eyes Absent Homolog 2, Eyes Absent Homolog 3, Eyes Absent Homolog 4-
H3S7ph--