Histone Lysine Ubiquitination

Ubiquitination is a bulky modification to the small histone peptides. Each ubiquitin group adds approx 8.5 kDa and there are multiple such moieties attached to single lysine in case of polyubiquitination. Ubiquitination generally targets proteins for proteasomal degradation but in the case of histones, it provides other signals important for gene regulation. Ubiquitination is catalyzed by a group of ligases named 'Lysine ubiquitinases' and which is known to occur on H2A, H2B, and H4.


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Sites of histone Lysine Ubiquitination
Site of modification Writers Erasers
H4K91ub1--
H2AK119ub E3 Ubiquitin-protein Ligase RING1, E3 Ubiquitin-protein Ligase RING2-
H2AK121ub--
H2BK120ub E3 Ubiquitin-protein Ligase BRE1A, E3 Ubiquitin-protein Ligase BRE1B-
H2BK121ub--