Histone Lysine Methylation

Methylation is one of the most well-studied modifications on histones. Mono (me1), di (me2) and trimethylation (me3) are the modifications which occur on the lysine residue. These modifications are carried out by a category of enzymes called 'lysine methyltransferases'.


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Sites of histone Lysine Methylation
Site of modification Writers Erasers
H4K20me1 N-lysine Methyltransferase KMT5A PHD Finger Protein 8
H4K20me2--
H4K20me3 Histone-lysine Methyltransferase 5B, Histone-lysine N-methyltransferase 5C-
H3K9me2 Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase EHMT2, Histone-lysine N-methyltransferase EHMT1 Lysine-specific Demethylase PHF2, Lysine-specific Demethylase 3A
H3K9me3 Aurora Kinase B, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SETDB2 Lysine (K)-specific Demethylase 4A, Lysine (K)-specific Demethylase 4B, Lysine (K)-specific Demethylase 4C, Lysine (K)-specific Demethylase 4D
H3K4me2 Histone-lysine N-methyltransferase MLL5, Protein Arginine N-methyltransferase 6 Lysine-specific Histone Demethylase 1A, Lysine-specific Demethylase 5B
H3K4me3 Histone-lysine N-methyltransferase MLL2, Protein Arginine N-methyltransferase 6 Lysine-specific Demethylase 5A, Lysine-specific Demethylase 5B, Lysine-specific Demethylase 5C
H3K4me1--
H3K36me1 Histone-lysine N-methyltransferase ASH1L, Histone-lysine N-methyltransferase, Histone-lysine N-methyltransferase SETD2-
H3K79me1 Histone-lysine N-methyltransferase, H3 Lysine-79 Specific-
H3K9me1 Histone-lysine N-methyltransferase EHMT2, Histone-lysine N-methyltransferase EHMT1, Histone-lysine N-methyltransferase EZH2 Lysine-specific Histone Demethylase 1A, Lysine-specific Demethylase 3A
H3K27me2 Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase EZH1 Lysine-specific Demethylase 6B
H3K27me3 Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase EZH1 Lysine-specific Demethylase 6B
H3K27me Histone-lysine N-methyltransferase EHMT2, Histone-lysine N-methyltransferase EHMT1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase EZH1, Protein Jumonji Lysine-specific Demethylase 6B
H1K34me--
H1k46me--
H1K63me--
H1K106me--
H1K26me--
H3K122me--
H3K36me2 N-lysine Methyltransferase SMYD2 Lysine (K)-specific Demethylase 2A, Lysine (K)-specific Demethylase 2B, Lysine (K)-specific Demethylase 8
H3K36me3- Ribosomal Oxygenase 1 , Lysine (K)-specific Demethylase 4A
H3K79me2 Histone-lysine N-methyltransferase, H3 Lysine-79 Specific-
H3K79me3 Histone-lysine N-methyltransferase, H3 Lysine-79 Specific-