Histone Lysine Acetylation

Histone acetylation is mostly associated with transcriptional activation. Acetylation (ac) occurs exclusively on lysine residues of histone peptides and is widely studied. It is catalyzed by a special category of enzymes called the 'lysine acetyltransferases'.


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Sites of histone Lysine Acetylation
Site of modification Writers Erasers
H4K5ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT5, Histone Acetyltransferase KAT6A, Histone Acetyltransferase KAT7 Histone Deacetylase 1
H4K8ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT5, Histone Acetyltransferase KAT6A, Histone Acetyltransferase KAT7 Histone Deacetylase 1
H4K12ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT5, Histone Acetyltransferase KAT6A, Histone Acetyltransferase KAT7 Histone Deacetylase 1
H4K16ac Histone-lysine N-methyltransferase MLL, Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT5, Histone Acetyltransferase KAT6A, Histone Acetyltransferase KAT7, Histone Acetyltransferase KAT8 Histone Deacetylase 1, NAD-dependent Protein Deacetylase Sirtuin-1
H1K25ac- NAD-dependent Protein Deacetylase Sirtuin-1
H2BK12ac Histone Acetyltransferase KAT2A Histone Deacetylase 1
H3K9ac Histone-lysine N-methyltransferase MLL, Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT6A Histone Deacetylase 1, NAD-dependent Protein Deacetylase Sirtuin-1
H3K14ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT6A Histone Deacetylase 1
H3K18ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT6A Histone Deacetylase 1
H3K24ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT6A Histone Deacetylase 1
H3K23ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT6A Histone Deacetylase 1
H2AK4ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT5 Histone Deacetylase 1
H2AK7ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT5 Histone Deacetylase 1
H2AK11ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT5 Histone Deacetylase 1
H2AK36ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT5 Histone Deacetylase 1
H3K56ac Histone Acetyltransferase KAT2A, Histone Acetyltransferase KAT2B, Histone Acetyltransferase KAT6A Histone Deacetylase 1, NAD-dependent Protein Deacetylase Sirtuin-2, NAD-dependent Protein Deacetylase Sirtuin-3