Histone Lysine Methyltransferase

Lysine methyltransferases are involved in catalyzing the transfer of methyl groups from S-Adenosyl methionine (SAM) to ε-amino group of target lysine residues. There are about twenty-two proteins which are involved in lysine methylation.

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Different Histone Lysine Methyltransferase
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Histone-lysine Methyltransferase 5BKMT5BH4K20me3
Histone-lysine N-methyltransferaseNSD1H3K36me1, H4K20me
Histone-lysine N-methyltransferase 5CKMT5CH4K20me3
Histone-lysine N-methyltransferase ASH1LASH1LH3K36me1
Histone-lysine N-methyltransferase EHMT1EHMT1H3K9me1, H3K9me2, H3K27me
Histone-lysine N-methyltransferase EHMT2EHMT2H3K9me1, H3K9me2, H3K27me
Histone-lysine N-methyltransferase EZH1EZH1H3K27me1, H3K27me2, H3K27me3
Histone-lysine N-methyltransferase EZH2EZH2H3K27me, H3K27me2, H3K27me3, H3K9me1
Histone-lysine N-methyltransferase MLLMLL1H3K4me, H4K16ac, H3K9ac, H3K9me2, H3R8me2
Histone-lysine N-methyltransferase MLL2MLL2H3K4me, H3K4me3
Histone-lysine N-methyltransferase MLL3MLL3H3K4me
Histone-lysine N-methyltransferase MLL5MLL5H3K4me, H3K4me2
Histone-lysine N-methyltransferase SETD1BSETD1BH3K4me
Histone-lysine N-methyltransferase SETD2SETD2H3K36me1
Histone-lysine N-methyltransferase SETD7SETD7H3K4me
Histone-lysine N-methyltransferase SETDB1SETDB1H3K9me3
Histone-lysine N-methyltransferase SETDB2SETDB2H3K9me3
Histone-lysine N-methyltransferase Smyd1SMYD1
Histone-lysine N-methyltransferase SMYD3SMYD3H3K4, H3K5m2 & 3
Histone-lysine N-methyltransferase SUV39H1SUV39H1H3K9me3
Histone-lysine N-methyltransferase SUV39H2SUV39H2H3K9me3
Histone-lysine N-methyltransferase, H3 Lysine-79 SpecificDOT1H3K79me1, H3K79me2, H3K79me3
N-lysine Methyltransferase KMT5AKMT5AH4K20me1
N-lysine Methyltransferase SMYD2SMYD2H3K4me, H3K36me2
Protein JumonjiJARID2H3K27me
SET Domain Containing 1A (Setd1a)SETD1A