Sites of histone lysine methylation
Site of modification Writers Erasers
H1K186me1 Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3-
H1K25me1 Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Lysine-specific demethylase 4D
H2BK5me1--
H3K27me1 Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase EZH1-
H3K27me2 Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase NSD3 Histone lysine demethylase PHF8, Lysine-specific demethylase 7, Lysine-specific demethylase 6B
H3K27me3 Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase NSD3 Lysine-specific demethylase 6A, Lysine-specific demethylase 6B
H3K36me1 Probable histone-lysine N-methyltransferase ASH1L-
H3K36me2 Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Probable histone-lysine N-methyltransferase ASH1L, N-lysine methyltransferase SMYD2 Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 8
H3K36me3 Histone-lysine N-methyltransferase SETD2, Probable histone-lysine N-methyltransferase NSD2 Lysine-specific demethylase 4A, Lysine-specific demethylase NO66
H3K79me1 Histone-lysine N-methyltransferase, H3 lysine-79 specific-
H3K79me3 Histone-lysine N-methyltransferase, H3 lysine-79 specific-
H3K4me1 Histone-lysine N-methyltransferase SETD7 Lysine-specific histone demethylase 1A
H3K4me2 Histone-lysine N-methyltransferase NSD3 Lysine-specific histone demethylase 1A, Lysine-specific demethylase 5A, Lysine-specific demethylase 5D
H3K4me3 Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase PRDM9, SET and MYND domain-containing protein 3 Histone lysine demethylase PHF8, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5A, Lysine-specific demethylase 5D, Lysine-specific demethylase 2B, Lysine-specific demethylase NO66
H3K56me--
H3K79me2 Histone-lysine N-methyltransferase, H3 lysine-79 specific-
H3K9me1 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Lysine-specific histone demethylase 1A, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B
H3K9me2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, PR domain zinc finger protein 2 Lysine-specific histone demethylase 1A, Histone lysine demethylase PHF8, Lysine-specific demethylase 7, Lysine-specific histone demethylase 1B, Lysine-specific demethylase 4D, Lysine-specific demethylase 4C, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B
H3K9me3 Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SETDB2 Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4D, Lysine-specific demethylase 4C
H4K5me--
H4K8me--
H4K20me1 Histone-lysine N-methyltransferase SETD8, Probable histone-lysine N-methyltransferase NSD2 Histone lysine demethylase PHF8
H4K20me2 Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2-
H4K20me3 Probable histone-lysine N-methyltransferase NSD2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2-