H3K36 dimethylation restricts the spread of H3K27 methylation mediated by PRC2. H3K36 dimethylation is observed at the site of DNA double strand breaks.

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H3K36me2 infosheet
Modified variants Histone H3.3
Modified Isoforms Histone H3.1, Histone H3.2
Writer/s Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, N-lysine methyltransferase SMYD2, Probable histone-lysine N-methyltransferase ASH1L
Eraser/s Lysine-specific demethylase 2A Lysine-specific demethylase 2B Lysine-specific demethylase 8
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Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K56me, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3, H4K5me, H4K8me