Phosphorylated H2AX Serine 139 is known to play important role in initiationg DNA damage response.

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H2AS139ph infosheet
Modified variants Histone H2A.x
Modified Isoforms-
Writer/s DNA-dependent protein kinase catalytic subunit, Serine-protein kinase ATM, Serine/threonine-protein kinase ATR
Eraser/s Protein phosphatase 1D Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 4 catalytic subunit
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Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3T80ph, H3Y41ph, H4S1ph